Publications Scientifiques

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Author: search.filters.author.Mebarki, Noudjoub

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    Microencapsulation of Thymus fontanesii extracts in pectin/casein : characterization, release behavior and storage stability
    (Springer, 2021) Mebarki, Noudjoub; Ziane, Hanifa; Fazouane, Fethia; Nabiev, Mohamed
    The present study aims to enhance the stability of Thymus fontanesii essential oil (TEO) and its main component thymol, and to prolong their release from encapsulation in pectin/casein matrix using complex coacervation and dried by freeze methods. Encapsulation efficiency, structural, physical and thermal properties of the microcapsules were determined. Storage stability of free and microencapsulated thyme extracts was evaluated and the controlled release kinetics of microcapsules in simulated gastrointestinal fluids were studied. Respectively, the successes of TEO and thymol encapsulation were confirmed by FTIR and X-ray diffraction analyses with encapsulation efficiency of 91.85 ± 1.35% and 93.66 ± 1.13%. The particle size ranged from 4.47 to 517.20 μm, presented a good thermal resistance and irregular shapes with rough surface. Prolonged release of the extracts from microcapsules was demonstrated with Higuchi behavior in gastric fluids while for simulated intestinal fluid, the non-Fickian transport was the main release mechanism. The microencapsulation of thyme extracts enhanced its thermal stability and proved that the thyme extracts were effectively well protected in microcapsules after a long time storage. The use of pectin/casein has shown good performance as a biodegradable matrix for protection and storage of thyme extracts, prolonging their storage stability and release. Therefore, these microcapsules can be useful ingredients for both food and pharmaceutical new products, to prolong bioavailability of bioactive compounds and to improve their thermal and storage stability
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    Evaluation of biological activities of Thyme extracts and their use as a naturalalternative to antibiotics for the reduction of pharmaceutical waste
    (Technology Publishing Group, 2019) Mebarki, Noudjoub; Nabiev, M.; Ziane, H.; Chader, H.; Fazouane, F.
    Excessive and improper use of chemical antibiotics is dangerous to human health and animals and causes an unhealthy environment. Hence, medicinal plants are expected to be the future alternative source of new antimicrobial products. The present study aimsto determine the chemical composition of Thymus fontanesiiBoiss. & Reut.essential oil (EO) then to isolate andcharacteriseitsmain constituent,thymol,and to evaluatetheir antibacterial and antioxidant activities. The oil was obtained by hydro-distillation from the aerial parts of T. fontanesii at yield of 3.4±0.2% and 06 main compounds were identified using GC/MS technique representing more than 99% of the oil composition. The major constituents were thymol (77.72%) and carvacrol (13.27%). The antimicrobial activity of our extracts was investigated in comparison with four synthetic antibiotics, using the disc diffusion and broth macro-dilution methods against 13 pathogenic bacteria. The antimicrobial evaluation showed that EO and thymol isolate exhibited high antibacterial activity against all the strains tested compared with the synthetic antibiotics, they were capable of inhibiting the growth of bacterial organisms tested with inhibition zones in the range of 10–58.53 mm. The EOwas the most active with MIC and MBC values of (0.035 mg/mL to 0.565 mg/mL). The antioxidant activity of our extracts was evaluated using 2,2-diphenyl-1-picrylhydrazyl (DPPH)radical scavenging method.The antioxidant activity revealed that the EO and thymol isolate demonstrated a very important anti-radical activity compared to the standards (ascorbic acid and BHT). T. fontanesii essential oil showed the strongest (p < 0.05) radical scavenging effect, with 50% inhibitory concentration (IC50) of 15.85 ± 0.23μg/mL. The results showed that the essential oil of T. fontanesii and thymol, its major compound, are an excellent alternative to synthetic antibiotics. They are of great interest because of their availability, non-toxicity and their friendship with the environment, and therefore can be useful for the food and pharmaceutical industries.
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    Preparation, characterization andin vitroantimicrobialactivity evaluation of thyme essential oil formulation totreat skin infections
    (University of El Oued, 2020) Mebarki, Noudjoub; Nabiev, M.; Ziane, H.; Chader, H.; Fazouane, F.
    The aim of the present study was to develop and evaluate a topical formulation containingThymus fontanesiiBoiss. & Reutessentialoilthat could serve as an antimicrobial agent forthe treatment of various skin diseases caused by bacteria,yeastanddermatophytes.Theselected formulationexhibited a significant antimicrobial activity against all tested strains,betterconsistency, good homogeneity, no skin irritation and good stabilityforsixmonths at25 ± 2°C.Our results demonstrate thatthe formulationcould beused safely as topicalpreparationto treat skin diseases caused by the tested microorganismsinto the future