Publications Scientifiques

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    Structural characterization of phytochemical content, antibacterial, and antifungal activities of Juglans regia L. leaves cultivated in Algeria
    (Elsevier, 2022) Bennacer, Amel; Sahir-Halouane, Fatma; Aitslimane-Aitkaki, Sabrina; Oukali, Zahia; Oliveira, Ivo Vaz; Rahmouni, Naima; Aissaoui, Mohammed
    Many microorganisms cause diseases to plants, animals and humans. Recently, natural compounds extracted from different medicinal and officinal plants have had a promising antimicrobial potential. In this present study, the antifungal and antibacterial activities of Juglans regia leaves cultivated in Algeria have been evaluated. The chemical composition was analyzed by GCMS spectroscopy. Total polyphenolic content (TPC), hydrolysable tannins content (HTC) and condensed tannin content (CTC) were assessed using Foilin ciocalteu, Potassium iodide and vanilline methods respectively. The antibacterial activity was tested against five bacterial strains and the antifungal activity was tested against seven fungal strains. The GC-MS profile of ethyl acetate fraction (tannic extract) revealed the presence of many interesting biomolecules we note: Phenol (0.19%), gaiucol (0.16%), catechol (0.65%), 2-Methoxy-4-vinylphenol (1.77%), eugenol (0.78%), (E)-coniferol (0.66%), 1, 5-naphthalenediol (2.01%) and 5-hydroxy-1, 4-naphthalenedione or juglone (0.18%). The tannic extract (ethyl acetate fraction) presented a high antifungal activity on Aspergillus terreus, Aspergillus ochraceus and Aspergillus Brasilliensis ATCC 16404 with percentage of growth inhibition of 77,033 ± 3,395, 73,327 ± 3,851 and 71,850 ± 0,641 respectively for the highest concentration. It also showed an interesting antibacterial activity against Klebseilla pneumoniae ATCC 70063 with minimal inhibitory concentration of 3.125 μg/ml comparing to the hydro-acetonic extract(MIC value). Our finding provides for the first time the chemical profiling of this species grown in Algeria and also an efficient and targeted natural approach to the discovery of classes of antibacterial and antifungal compounds for various applications
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    Synthesis, biological activities and molecular docking study of 3-(3-oxobutanoyl)-2H-chromen-2-one derivative
    (Elsevier, 2021) Benazzouz-Touami, Amina; Hikem-Oukacha, Djamila; Ould Lamara, Kamilia; Halit, Sabrina; Terrachet-Bouaziz, Souhila; Makhloufi-Chebli, Malika
    Herein, we report the highly efficient total synthesis of a series of 3-(3-oxobutanoyl)-2H-chromen-2-one derivatives from salicylaldehyde(s) and 4‑hydroxy-6-methyl-2H-pyran-2-one (TAL) using Na2S2O3 as green and efficient catalyst. Structure elucidation of the products has been accomplished based on FT-IR, mass spectroscopy, 1H NMR and 13C NMR spectroscopy. The in vitro antioxidant activities of the drugs 3-(3-oxobutanoyl)-2H-chromen-2-one were tested by the quantitative 1,1-diphenyl-2-picrylhydrazyl (DPPH.) radical scavenging activity method. The compounds 3b, 3c and 3e proved to be the most active, showing high capacity to deplete the DPPH radicals. All synthesized compounds were screened for their antimicrobial activities and the results show that only 3f was active against bacteria Staphylococcus aureus compared to antibiotic used as reference. In addition, all synthesized compounds were docked with FtsZ from S. aureus protein using AutoDock 4 software. The results suggest that 3f binds with FtsZ protein with lower energy and undergoes good interactions with the active site amino
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    Transition-metal complexes of N,N′-di(4-bromophenyl)-4-hydroxycoumarin-3-carboximidamide : synthesis, characterization, biological activities, ADMET and drug-likeness analysis
    (Elsevier, 2021) Belkhir-Talbi, Drifa; Ghemmit-Doulache, Naima; Terrachet-Bouaziz, Souhila; Makhloufi-Chebli, Malika; Rabahi, Amal; Ismaili, Lhassane; Silva, Artur M.S.
    Coordination compounds of N,N’-di(4-bromophenyl)-4-hydroxycoumarin-3-carboximidamide (L1) were synthesized via the reaction of Cu (II), Co (II) and Zn (II) salts in molar ratio 1 : 1 in the presence of ammoniac as basic media. The Ligands and the complexes formed were characterized using FT-IR, UV–visible and fluorescence spectrophotometric analyses, mass spectrometry, elemental analyses and NMR spectroscopy. It was concluded that N,N’-di(4-bromophenyl)-4-hydroxycoumarin-3-carboximidamide (L1) coordinated as a mono ligand for all the complexes; it also coordinated via the –OH and –NH groups. The electrochemical behaviour of these compounds was determined by cyclic voltammetry. The synthesized compounds were screened for their antimicrobial and antioxidant activities. All the complexes except that of copper show good activities against the S. aureus and those of cobalt and zinc have very interesting diameters of inhibition but lower antioxidant activity than the ligand L1. Parameters drug-likeness and ADMET (Absorption, Distribution, Metabolism, and Excretion) properties have been calculated