Publications Scientifiques
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Item Impact of gamma irradiation on phytochemical composition, and biological activities of Lepidium sativum seeds extract(Walter de Gruyter GmbH, 2024) Hadj Rabia, Samia; Debib, Aicha; Eddaikra, Atika; Aberkane-Mchebbek, Lila; Nouri, Ramy; Benmoussa, Fatima; Mokhtari, Amine; Medjber, Sarah; Mansouri, Belkacem; Messaoudi, MohammedThe main objective of this research is to assess how gamma radiation influences the chemical composition and activities such as antioxidant, antimicrobial and anticancer activities of Lepidium sativum (L. sativum) seeds. Methanolic extracts were obtained through a 24 h maceration process from L. sativum seeds exposed to various doses of gamma irradiation. Phytochemical screening involved precipitation and staining reactions, with the antioxidant potential assessed using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay. Antimicrobial activity was evaluated through a diffusion test on agar medium, while the cytotoxic potential on the lung cancer line “A-549 cells” was examined using the 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) assay. Qualitative analysis of the extracts identified preserved bioactive constituents after irradiation. Additionally, quantitative analysis indicated a significant rise in the total content of polyphenols and flavonoids under radiation, accompanied by an enhanced reducing power compared to the control. The antimicrobial and cytotoxic capabilities also improved, evident in increased growth inhibition zones for certain microbial strains and reduced viability rates of A549 cells. These results show promise and warrant further investigation into the potential of gamma radiation to enhance additional biological effects of plants.Item Coordination of new palladium (II) complexes with derived furopyran-3,4‑dione ligands: Synthesis, characterization, redox behaviour, DFT, antimicrobial activity, molecular docking and ADMET studies(Elsevier, 2022) Fahima Dechouk, Lamia; Bouchoucha, Afaf; Abdi, Yamina; Si Larbi, Karima; Bouzaheur, Amal; Terrachet-Bouaziz, SouhilaThe synthesis, characterization, theoretical study, electrochemical behaviour and biological activity of new series of Pd (II) complexes were reported with 6-methyl-2-(phenyl(p-tolylamino)methyl)-4H-furo[3,2-c]pyran-3,4(2H)-dione derived ligands. [MLCl2] is the proposed general formula of complexes. The synthesized complexes were prepared and experimentally characterized by elemental analysis, SEM-EDX, FTIR, 1HNMR, UV-Visible spectroscopy, magnetic measurement, conductivity and thermal analysis. FTIR spectroscopy has revealed the coordination mode of complexes through nitrogen and oxygen atoms. The Density Functional Theory calculation was applied to optimize the geometric structure of complexes, whereas Orbital Molecular Frontiers calculations allowed to define their stability. The experimental electronic spectra and magnetic measurement results approved a square planar geometry for all complexes. These results correlate with theoretical calculations. The electrochemical behaviour of ligands and complexes were determined by cyclic voltammetry, which reveal different redox processes of Pd (II) couples for the three complexes. The antimicrobial activity of all compounds was evaluated against different micro-organisms using agar disc-diffusion method. Most of compounds exhibit a remarkable inhibition against standard yeasts and S. aureus Gram positive bacteria. The ADMET study was carried out to predict pharmacokinetic and toxicity of synthesised compounds. Molecular Docking of HL3 and Pd-HL3 against S. aureus was applied in order to study their molecular interactionsItem Synthesis, biological activities of chalcones and novel 4-acetylpyridine oximes, molecular docking of the synthesized products as acetylcholinesterase ligands(Elsevier, 2022) Ould Lamara, Kamilia; Makhloufi-Chebli, Malika; Benazzouz-Touami, Amina; Terrachet-Bouaziz, Souhila; Robert, Anthony; Machado-Rodrigues, Carine; Behr, Jean-BernardHeterocyclic chalcones were synthesized by reaction of 4-acetylpyridine with the corresponding aromatic aldehydes under Claisen Schmidt conditions. These chalcones were used as starting material for the synthesis of oximes in the presence of hydroxylamine hydrochloride. The structures of the synthesized compounds were confirmed by IR, 1H NMR, 13C NMR and ESI-MS, HRMS spectral analyses. All the synthesized compounds were evaluated for their antioxidant activity by DPPH• method and their in vitro antimicrobial activity by disk diffusion method against two Gram-negative bacteria, one Gram-positive bacteria and two fungal strains (C. albicans and A. niger). The results showed that the synthesized compounds did not display significant antioxidant activity. However, compounds 3b, 3d, 3f, 3h, 3i showed excellent antibacterial activity better than the standard drug against the bacterial strain S. aureus (ATCC 25923). The two compounds 3c, 3d proved very active against the fungal strain A. niger (MIC= 7.81 µg/ mL, 15.62 µg/mL respectively) while the antifungal drug used as reference (Fluconazole) was inactive. Molecular docking and molecular dynamics results revealed that the synthesized compounds, 4e, 4c, and 5j, were involved in a large number of favorable interactions with the active site residues of the acetylcholinesterase protein, which can stabilize the ligands in the active site and increase their affinitiesItem Biotreatment on cellulose fluff pulp : quaternary ammonium salts finish and grafting with β -cyclodextrin(2009) Ghemati, Djamila; Aliouche, Djamel; Oudia, Atika; Lamouri, SaadFor its potential performances to be expanded, cellulose needs to be processed in different ways. Therefore, an object of the present work was to provide a chemical modification of cellulose through: a specific finish with two quaternary ammonium salts (namely Aliquat 336 and Aliquat 1529, respectively). Chemical grafting of β -cyclodextrin derivative ( β -CD) onto fibers followed by the inclusion of benzoic acid in the grafted CD cavities as a probe chemical. Physicochemical properties and performances of the untreated and treated fibers have been determined with infrared spectra, microscopy, swelling measurements, antimicrobial finishing tests, and dye adsorption. Our results show that cellulose fibers can be efficiently modified with no significant changes in its structural and surface properties; the treated fibers show an attractive behavior in swelling, dye adsorption and antibacterial activity