Smaani, BillelNafa, FaresBenlatrech, Mohamed SalahMahdi, IsmahanAkroum, HamzaAzizi, Mohamed walidHarrar, KhaledKanungo, Sayan2024-09-192024-09-1920242190-4286https://www.beilstein-journals.org/bjnano/articles/15/80https://doi.org/10.3762/bjnano.15.80https://dspace.univ-boumerdes.dz/handle/123456789/14292Over the last few decades, field-effect transistor (FET)-based biosensors have demonstrated great potential across various industries, including medical, food, agriculture, environmental, and military sectors. These biosensors leverage the electrical properties of transistors to detect a wide range of biomolecules, such as proteins, DNA, and antibodies. This article presents a comprehensive review of advancements in the architectures of FET-based biosensors aiming to enhance device performance in terms of sensitivity, detection time, and selectivity. The review encompasses an overview of emerging FET-based biosensors and useful guidelines to reach the best device dimensions, favorable design, and realization of FET-based biosensors. Consequently, it furnishes researchers with a detailed perspective on design considerations and applications for future generations of FET-based biosensors. Finally, this article proposes intriguing avenues for further research on the topology of FET-based biosensors.enBiomolecule detectionBiosensorsCharge modulationDielectric modulationField-effect transistorArticle