Pd-Catalyzed Coupling of Bromo-N-(β-glucopyranpsyl)quinolin-2-ones with Amides: Synthesis of N-glucosyl-6BrCaQ Conjugates with Potent Anticancer Activity

Redjdal, WafaBenmahdjoub, SaraThanh Hyen Luong, ThiBenmerad, BelkacemLe Bideau, FranckVergnaud-Gauduchon, JulietteMessaoudi, Samir2024-05-082024-05-0820241860-7179https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/cmdc.202400195https://doi.org/10.1002/cmdc.202400195https://chemistry-europe.onlinelibrary.wiley.com/doi/epdf/10.1002/cmdc.202400195https://dspace.univ-boumerdes.dz/handle/123456789/13889A series of N-glycosyl- 6BrCaQ conjugates was synthesized through a Pd-catalyzed cross-coupling reaction between brominated N-glycosyl quinolin-2-one derivatives and various nitrogen nucleophiles. Antiproliferative assays revealed that this new series of analogues represents a promising class of antitumor compounds as illustrated by the high biological activity observed for several derivatives towards different cancer cell lines compared to the non-glycosylated congeners.enN-glycosidesHPS90TRAP1Buchwald-Hartwig Cross-CouplingAntiproleferative activityPd-Catalyzed Coupling of Bromo-N-(β-glucopyranpsyl)quinolin-2-ones with Amides: Synthesis of N-glucosyl-6BrCaQ Conjugates with Potent Anticancer ActivityArticle