Browsing by Author "Alves, Gilberto"

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    Dietary use of Rosmarinus officinalis and Thymus vulgaris as anticoccidial alternatives in poultry
    (Elsevier, 2021) Aitfella Lahlou, Radhia; Bounechada, Mustapha; Mohammedi, Arezki; Silva, Luís R.; Alves, Gilberto
    Coccidiosis is a parasitic disease caused by protozoa belonging to the genus Eimeria and whose propagation has a tremendous economic impact on poultry production. The parasite develops in the intestinal tract and causes disturbances in homeostasis that may lead to the death of the animal. Anticoccidial drugs and vaccination are the main preventive measures used against this disease. However, the rapid spread of drug resistance and the emergence of environmental pollutants have led to search other alternatives that do not hinder the health and productivity of broilers. The use of medicinal plants or plant-derived products could be one of these approaches; in fact, plants are reservoirs of bioactive compounds that could be developed as new chemical entities. Two members of the Lamiaceae family, Rosmarinus officinalis and Thymus vulgaris included in the Algerian pharmacopoeia have been reviewed herein, as well as their anticoccidial activity. We discuss their potential uses as natural growth promoters, referring their phytochemical constituents and biological properties that could play a crucial role in improving the symptoms caused by coccidiosis in poultry
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    Potential activity of abrantes pollen extract : biochemical and cellular model studies
    (MDPI, 2021) Gonçalves, Ana C; Lahlou, Radhia Aitfella; Alves, Gilberto; Garcia-Viguera, Cristina; Moreno, Diego A; Silva, Luís R
    The aim of this study was to determine the grain composition and (poly)phenolic profile of pollen from Abrantes (Portugal), as well as its antioxidative and antidiabetic properties, and abilities to protect human erythrocytes against induced hemoglobin oxidation, lipid peroxidation, and hemolysis. The phytochemical profile of the Abrantes' bee pollen revealed twenty phenolic compounds, identified by high-performance liquid chromatography with electrospray ionization mass spectrometry coupled with photodiode array detection. Among them, quercetin derivatives were the most abundant. Concerning the biological potential, the pollen extract showed notable capacity for 2,2-diphenyl-1-picrylhydrazyl, nitric oxide, and superoxide radicals, as well as for inhibition of α-glucosidase action, and protection of human erythrocytes against oxidative damage. Non-cytotoxic effects regarding the NHDF normal cell line, human adenocarcinoma Caco-2, and human liver HepG2 cells were observed. The results obtained contributed to further research on modes of action related to oxidative damage and metabolic health problems, to generate deeper knowledge of potential health-promoting effects to develop novel pharmaceutical drugs, nutraceuticals, and dietary supplements