Browsing by Author "Benabdelkader, Tarek"

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Characterization of the chemical diversity in essential oils from vegetative and reproductive organs of ammodaucus leucotrichus subsp. leucotrichus coss. & dur. growing in Algeria
(Taylor & Francis, 2021) Neghliz-Benabdelkader, Hayat; Benabdelkader, Tarek; Halladj, Fatima; Jullien, Frédéric
Ammodaucus leucotrichus is one of the desert aromatic plants most commonly used in Algerian and Moroccan traditional medicine. The plant is a rich source of bioactive compounds especially essential oils (EOs). In this work, we reported for the first time the characterization of the chemical composition of EOs from vegetative and reproductive organs of this species. Root, stem/leaf, flower and fruit EOs were obtained by Clevenger-hydrodistillation and analyzed by gas chromatography-mass spectrometry (GC-MS). The percentage yield of EOs varied between 0.52 and 3.04 % (w/w, based on dry weight). ATotal of 89 (90.0-97.7 %) components were identified. The EO chemical profiles of plant organs were different from each other exhibited a significant chemo-diversity. (Z)-falcarinol (24.3 %), β-bisabolene (19.6 %) and myristicin (14.0 %) were the major constituents in root oil; methyl eugenol (33.5 %), α-pinene (26.3 %) and muurola-4,10(14)-dien-1-β-ol (10.5 %) in stem/leaf oil; methyl eugenol (24.9 %), β-bisabolene (16.0 %) and geranyl acetate (14.5 %) in flower oil; perillaldehyde (53.7 %) and limonene (25.3 %) in fruit oil
Comparative analysis of the chemical constituents and in vitro antioxidant activities of different aqueous extracts of cistanche phelypaea (L.) Cout. from Algeria
(Elsevier, 2022) Rahim, Meriem Zohra; Prinsi, Bhakti; Espen, Luca; Benabdelkader, Tarek; Nabiev, Mohamed; Houali, Karim
Cistanches herba are well-known for their nutritional and therapeutic effects, but only few reports are available about the species Cistanche phelypaea (L.) Cout. and studies of aqueous extracts are scarce. This study aimed to elucidate the impact of aqueous extraction methods including decoction, infusion and cold maceration from C. phelypaea roots on phytochemical composition and in vitro antioxidant activities of the extracts. In order to accomplish this, determinations of total phenolic and flavonoid contents, liquid chromatography electrospray ionization mass spectrometry (LC/ESI-MS and LC/ESI-MS/MS) analyses and in vitro antioxidant activity studies were carried out. All extracts had significant levels of total phenolic content, but the decoction possessed the highest concentration and no significant difference was observed between infusion and cold maceration. Concerning flavonoids, decoction and infusion possessed the highest concentrations. Data obtained from LC/ESI-MS and LC/ESI-MS/MS analyses showed similar qualitative profiles for all aqueous extracts with 14 characteristic chromatographic peaks in negative mode and 6 in positive mode, which allowed the tentative identification of syringin, 14 phenylethanoid glycosides and 5 iridoids, including 5 pairs of isomers. However, significant variations were recorded for the relative abundance of some compounds depending on the method that was employed. Hot extraction procedures, decoction and/or infusion were more efficient in extracting acteoside, isoacteoside and two molecules corresponding to isomers of 2ʹ-acetylacteoside/tubuloside B, and it seems that a longer time of heating-extraction was required for an improved extraction of isoacteoside, and one of the two isomers of 2ʹ-acetylacteoside/tubuloside B, as decoction gave a significant higher amount of these compounds. However, 8-epiloganic acid and cistanoside F, with their respective isomers, and syringin were more extractable by the cold maceration process. All extracts had similar antioxidant properties in scavenging DPPH radical and total antioxidant activity assays, with the exception of the ferric-reducing power activity assay, in which cold maceration exhibited a significantly less potent activity. Aqueous extracts of C. phelypaea roots present an interesting antioxidant potential which is related to the synergistic effects of several antioxidant compounds
The effect of ultrasound Pre-treatment on the yield, chemical composition and antioxidant activity of essential oil from wild lavandula stoechas L
(Taylor & Francis, 2018) Chekoual, Lilia; Aissat, Abdelkader; Ait-Kaci Aourahoun, Karima; Benabdelkader, Tarek
Essential oil composition and antibacterial activity of Pteridium aquilinum (L.) Kuhn
(Springer link, 2020) Bouchekouk, Cheimâa; Kara, Fatima Zohra; Tail, Ghania; Saidi, Fairouz; Benabdelkader, Tarek
The present work aims to study the chemical composition of Pteridium aquilinum (L.) Kuhn essential oil and its antibacterial activity against three important phytopathogenic Gram-negative bacteria: Erwinia amylovora, Pectobacterium carotovorum subsp. caroto-vorum, and Pseudomonas savastanoi pv. savastanoi
Essential oils from wild populations of algerian lavandula stoechas L. : composition, chemical variability, and in vitro biological properties
(Wiley Periodicals, 2011) Benabdelkader, Tarek; Zitouni, Abdelghani; Guitton, Yann; Jullien, Frédéric; Maitre, Dany; Casabianca, Hervé; Legendre, Laurent; Kameli, Abdelkrim
Lavender inflorescence : a model to study regulation of terpenes synthesis
(Taylor & Francis, 2010) Guitton, Yann; Nicolè, Florence; Moja, Sandrine; Benabdelkader, Tarek; Valot, Nadine; Legrand, Sylvain; Jullien, Frédéric; Legendre, Laurent
A novel anti-candidiasis cream formulation based on Melissa officinalis and Lavandula stoechas essential oils synergism
(Taylor & Francis, 2024) Rezzoug, Hamida; Bouchenak, Ouahiba; Boudjema, Khaled; Benabdelkader, Tarek; Felix, Tomi; Pierre, Tomi; Djilani, Selma
Candida albicans is the yeast strain that causes candidiasis, which can vary from minor skin and soft tissue infections to potentially fatal infections like candidemia, which can get worse due to drug resistance. Natural substances could be used as antifungal agents’ alternatives, especially against C. albicans. Thereby, the main objective of this research was to define the chemical content and evaluate the bioactivity of Melissa officinalis and Lavandula stoechas essential oils (EOs). Additionally, the synergistic effect of both oils was carried out against C. albicans, in order to formulate EOs combination-based creams. Their chemical compositions were analyzed using the combination of gas chromatography-flame ionization detector (GC-FID) and GC-mass spectrometry (GC-MS). The interaction with both EOs was also evaluated and analyzed by GC-FID and GC-MS, and the development of anti-candidiasis formulations was tested in vitro. Our results showed that the main compounds of M. officinalis EO (MOEO) were geranial (35.7%) and neral (24.1%), whereas, 1.8-cineole (61.9%) was dominant in Lavandula stoechas essential oil (LSEO) and the main compounds of the combination between both EOs were 1,8-cineole and geranial. Moreover, the MOEO exhibited substantial antifungal action against all tested microorganisms with MIC values ranging from 0.125 to 0.0019. This EO also showed synergistic effect when combined with that of L. stoechas. These findings, suggest the good bioactive qualities of the topical creams developed against C. albicans, revealing their potential to be possibly applied as an antifungal agent in industrial pharmaceutics.