Browsing by Author "Kichou, Noura"

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    Decomposition of Hydrogen Peroxide in Presence of DimethylglyoximatoNickel Complexes as Catalysts: Catalase-Like Activity
    (ISRES Publishing, 2024) Kichou, Noura; Guechtouli, Nabila; Merrad, Anissa; Hank, Zakia
    The development in coordination chemistry in recent years raise hopes that synthetically produced metal complexes could mimic many biochemical systems widely found in nature. There is a certain analogy between nature and organometallic systems. A large number of biological metal complexes are known, including oxygen carriers like hemoglobin in the blood, which contains a ferrous ion; respiratory enzymes; those involved in protein hydrolysis; and vitamin B12, which is only active in the presence of cobalt in the trivalent state. The Nickel (III), in addition to Fe-S clusters, was an essential component in hydrogenases. Since then, nickel (III) complexes have been used as models for studying the catalytic function of certain enzymes (hydrogenases). In this context, a study on the catalytic ability of dimethylglyoximato-nickel complexes as peroxiredoxases in the dismutation or oxidation of hydrogen peroxide was conducted. The results were discussed, commented upon, and a reaction mechanism was proposed. The results seem encouraging, regarding the effect of the complexation on catalase-like activity.
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    Synthesis, Characterization, and in Silico ADMET Evaluation of Transition Metal Complexes Based on Ortho-Phenylenediamine and Its Derivatives
    (ISRES, 2025) Kichou, Noura; Guechtouli, Nabila; Taferguennit, Manel; Ighilahriz, Karima
    A series of cobalt (II), nickel (II), and zinc(II) complexes were synthesized using orthophenylenediamine and its two substituted derivatives (methyl- and nitro-ortho-phenylenediamine) as ligands. These complexes were isolated and characterized using various analytical techniques, including Elemental analysis, infrared (IR) and UV-Visible spectroscopy, gravimetry, and conductimetry. Conductimetric analysis revealed that all the complexes exhibit a non-electrolytic behavior in solution, indicating the absence of free ions in the medium. IR spectroscopic studies allowed the identification of the coordination modes of the ligands to the metal centers. Comparison of the IR spectra of the complexes with those of the free ligands highlighted the involvement of the amine (-NH₂) groups in coordination with the metal, confirming their role as the primary coordination sites. UV-Visible spectroscopic analysis was used to determine the geometry of the complexes. The observed absorption bands are characteristic of an octahedral coordination around the metal ions, which is consistent with the expected electronic transitions for these systems. In recent years, the integration of computational methodologies has considerably enhanced the ability to predict the toxicity and pharmacokinetic behavior of bioactive compounds, thereby streamlining the early stages of drug discovery. Within this framework, the present study investigates the ADMET profiles - Absorption, Distribution, Metabolism, Excretion, and Toxicity as well as the drug-likeness properties of the synthesized ligands and their corresponding transition metal complexes.