Publications Scientifiques

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Author: search.filters.author.Terrachet-Bouaziz, SouhilaHas files: Yes

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    Synthesis, characterization, theoretical studies, ADMET and drug- Likeness analysis: Electrochemical and biological activities of metal complexes of 3-(2-hydroxybenzoyl)-2H-chromen-2-one
    (Elsevier, 2019) Belkhir-Talbi, Drifa; Makhloufi-Chebli, Malika; Terrachet-Bouaziz, Souhila; Hikem-Oukacha, Djamila; Ghemmit, Naima; Ismaili, Lhassane; M.S Silva, Artur; Maamar, Hamdi
    Coordination compounds of 3-(2-hydroxybenzoyl)-2H-chromen-2-one were synthesized by the reaction of Cu(II), Co(II) and Zn(II) salts in molar ratio 1: 1 in basic media. The compounds formed were characterized using infrared, Uv–vis spectrophotometric analyses, mass spectrometry, elemental analyses and NMR spectroscopy. It was concluded that 3-(2-hydroxybenzoyl)-2H-chromen-2-one coordinated as a mono ligand for all the complexes; it also coordinated via the two carbonyl moieties. The electrochemical behavior of these compounds was determined by cyclic voltammetry. The synthesized compounds were screened for their antimicrobial and antioxidant activities. The complexes exhibited good antimicrobial activity against Staphylococcus aureus (ATCC 25923) and good antioxidant activity. Parameters drug-likeness and ADME properties are calculated.
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    Novel palladium (II) complexes with iminocoumarin ligands : synthesis, characterisation, electrochemical behaviour, DFT calculations and biological activities, ADMET study and molecular docking
    (2022) Kerflani, Asma; Si Larbi, Karima; Rabahi, Amal; Bouchoucha, Afaf; Zaater, Sihem; Terrachet-Bouaziz, Souhila
    New Palladium (II) complexes with a series of iminocoumarin derivatives have been synthesized and charac- terized by analytical analysis, spectral methods, magnetic measurements and thermal studies. The experimental results indicated that the Pd(II) complexes are coordinated to the bidentate iminocoumarin derivatives with a distorted square planar geometry. The DFT calculations were performed in order to optimize the geometric structures, to calculate structural parameters and to explain the chemical reactivity of the synthesized com- pounds. Electrochemical behaviour of the synthesized compounds was studied by cyclic voltammetry. The antioxidant activity of free ligands and their Pd(II) complexes have been evaluated using the DPPH method. The antimicrobial activity was also evaluated in Vitro against two Gram-negative (E. coli, Klebsiella pneumonia), two gram-positive (Staphylococcus aureus, Enterococcus faecalis) and three fungal strains (Candida albicans, Candida tropicalis and Aspergillus niger) using the agar-diffusion method. The ADMET study was also accomplished in order to predict pharmacokinetic and toxicity of the synthesized compounds. Finaly, and in order to study the molecular interaction of the ligand L3 and its corresponding Pd(II) complex with the microbial enzymes; Docking studies were employed