Optimization of a dermatological cream process formulation from Atractilys Gummifera L roots

Abstract

Atractilys Gummifera L or glue thistle,is one of the medicinal plants of the Mediterranean area. Belonging to the Asteraceae family, it is used in traditional medicine in various ways (maceration, decoction and fumigation). The rhizome of this plant is used as a healing agent in traditional Algerian medicine: it helps to heal burns. The aim of our work is to optimize the formulation process of a cream for dermatological application based on the roots of Atractilys Gummifera L, by using the methodology of experimental design. The physicochemical characterization of the underground part of this plant reveals a richness in organic substances (sugars 8.5%, lipids 2.29%, Brix degrees 33.34%), and mineral substances (ashes 4.21%). The study of the various parameters considered influential on the formulation process revealed that the optimal conditions for a more stable cream are: the solid (rhizome) / liquid (water) ratio 0.4 (m / V), the stirring time for 15 minutes and the stirring speed 500 rpm. The cream obtained has a rheofluidic (or pseudoplastic) behaviour, which can be described by the Casson model. This behaviour is suitable for a cream for dermatological application