Publications Internationales

Now showing 1 - 5 of 5

In Vivo Wound-Healing and Molecular Docking Studies Support the Traditional Use of Arisarum vulgare Aqueous Extract
(John Wiley and Sons Ltd, 2025) Bouafia, Zineb; Boudjelal, Amel; Bouaziz-Terrachet, Souhila; Smeriglio, Antonella; Bouhenna, Mustapha Mounir; Yıldız, Ilyas; Demirtas, Ibrahim; Trombetta, Domenico
In Algerian traditional medicine, Arisarum vulgare O. Targ. Tozz. (Araceae), locally known as “Elbgouga,” is widely used to treat eczema, wounds, and burns. The aim of this study was to investigate, for the first time and by using in vivo and in silico molecular docking techniques, the possible effects of A. vulgare ultrasound-assisted aqueous extract (AVAE) on wound healing. The phytochemical profile was elucidated by LC-ESI-MS/MS analysis. Wistar albino rats were used to evaluate the AVAE ointment's acute cutaneous toxicity and wound-healing potential (1%, 2%, and 5% AVAEO). Through in silico investigations, TNF-α, IL-1β, MMP-9, TGF-β, VEGF, and EGFR were examined as possible therapeutic targets. Twenty-seven phytochemicals, belonging mainly to the flavonoids and phenolic acids' class, were identified and semi-quantified. The 5% AVAEO-treated group showed a significantly greater (p < 0.001) wound contraction (8–20 days) with respect to untreated and petroleum jelly groups, whereas no statistically significant difference was observed with respect to the Madecassol-treated group. On the contrary, the two lower doses (1% and 2% AVAEO) showed no statistically significant effects. Docking studies showed that A. vulgare bioactive compounds may have therapeutic effects on wound healing by targeting with high affinity TNFα, IL-1β, MMP-9, TGF-βR1, VEGF, and EGFR, counteracting inflammation, angiogenesis, and oxidative unbalance, and promoting wound repair. This study demonstrated that AVAE possesses in vivo wound healing properties and no dermal toxicity, shedding light also on the potential therapeutic targets involved
Analgesic effect of Centaurium erythraea and molecular docking investigation of the major component swertiamarin
(Taylor and Francis, 2023) Chabane, Sarra; Boudjelal, Amel; Bouaziz-Terrachet, Souhila; Spinozzi, Eleonora; Maggi, Filippo; Petrelli, Riccardo; Tail, Ghania
Centaurium erythraea Rafn is employed in Algerian traditional medicine for treating pain. The analgesic activity of the ethanolic extract (EE) from the flowering aerial parts of this plant was examined, and molecular docking of the main bioactive compound was performed. The EE, characterised by the iridoid swertiamarin, was administered to Wistar albino rats in pain models. Peripheral analgesic activity was evaluated using the acetic acid-induced writhing test, and a hot plate test was performed for central antinociceptive activity evaluation. Treatment with EE significantly decreased rats’ writhing induced by acetic acid suggesting peripheral analgesic activity. Furthermore, the elevation of mean basal reaction time in the hot plate method indicated central analgesic activity. Molecular docking studies showed good docking energy with acceptable binding interactions of swertiamarin with cyclooxygenase-2 protein. This supports the analgesic activity of C. erythraea EE, justifying the traditional use of the plant as an analgesic herbal remedy.
Design and one-pot synthesis of some new [3,5-di(4’,5’-diphenyl-2’-substituted)-1h-imidazol-1-yl]]-1h-1,2,4-triazole derivatives: In silico admet and docking study, antibacterial and antifungal activities evaluation
(Japan Institute of Heterocyclic Chemistry, 2021) Hadhoum, N.; Hadjadj-Aoul, F.Z.; Hocine, Smain; Bouaziz-Terrachet, Souhila; Abdoun, A.; Seklaoui, N.; Boubrit, F.; Abderrahim, W.; Mekacher, L.R.
In this paper, a new series of some [3,5-di(4’,5’-diphenyl-2’-substituted)-1H-imidazol-1-yl)]-1H-1,2,4-triazole derivatives (C1-C9) were efficiently synthesized by a one-pot three component reaction via a coupling of benzil, aldehydes and 3,5-diamino-1,2,4-triazole and using ceric ammonium nitrate as a catalyst. The structures of the newly compounds were investigated by IR, 1H NMR, 13C NMR and UV-visible spectroscopy. The in vitro antibacterial and antifungal activities showed that the C9 is the most active compound. The C9 docking study revealed the best mode of binding in the active site of the cytochrome P450 lanosterol 14α-demethylase. All the synthesized compounds were predicted as non-carcinogens and demonstrated acceptable pharmacokinetic profile in blood brain barrier (BBB) and human intestinal absorption (HIA)
Theoretical investigation of dicarboxamide mono copper (II) and novel transition metal complexes : structural, chemical reactivity, vibrational and in-silico biological analysis
(Elsevier, 2019) Guechtouli, N.; Zaater, S.; Kichou, N.; Bouaziz-Terrachet, Souhila; Meghezzi, H.
We are interested to the theoretical investigation of new synthesized dicarboxamide mono copper(II) complex, and other hypothetical one by modifying the transition metal by another one of the same series as (Mn(II), Fe(II), Fe(III), Co(II), Co(III), Cu(II), Ni(II) and Zn(II)). The aim of this study is to predict other stable complexes which can be synthesized and which would have comparable or better biological activity than that obtained experimentally, and predict their synthesis. For this purpose, structural, energetic, spectroscopic (IR, UV–Visible and NMR) properties have been evaluated at the DFT level. The stability of the considered complexes has been studied in the basis of the binding energies. The in-silico biological properties and chemical reactivity descriptors of hypothetical and synthesized compounds have been calculated and discussed
Clinical characteristics of Algerian subjects with MODY p.R85W glucokinase mutation- in silico assessment of p.R85W effect on glucokinase structure and function
(Elsevier, 2018) Bouldjennet, F.; Hireche, A.; Kechout, N.; Bouaziz-Terrachet, Souhila; Azzouz, M.; Mihoubi, Esma; Aissou, Abdallah; Touil-Boukoffa, C.; Attal, Nabila; Raache, Rachida

Publications Internationales

Browse

Filters

Settings

Sort By

Results per page

Search Results