Publications Internationales

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    Synthesis of resin from Alfa stem to applied as an adhesive corrosion-resistant coating
    (Springer Nature link, 2025) Toubal, Sara; Aribi, Chouaib; Chentir, Imen; Safi, Brahim; Bouaissi, Aissa; Saidi, Mohammed
    The demand for eco-friendly alternatives to petrochemical-based phenolic resins has risen due to increasing concerns about climate change, environmental impact, and manufacturing costs. This study introduces a sustainable approach by partially replacing phenol with lignin, a natural polymer rich in phenolic groups, extracted from Alfa stems. Using the alkaline method, 50% of phenol was substituted with lignin to synthesize phenol–formaldehyde (PF) resins. The synthesized lignin–phenol– formaldehyde (LPF) resin was characterized to verify its chemical structure and physical properties. The resin demonstrated significant antioxidant and antibacterial activity, particularly against E. coli and P. aeruginosa gram-negative bacteria at a concentration of 20 mg/ml. Additionally, the lignin substitution provided notable advantages over conventional industrial resin formulations. The lignin’s properties closely influenced the formulation of the LPF resin, making it similar to the reference CPF resin. However, the lower intensity observed in the LPF resin suggests potential limitations in the methylol group formation compared to the CPF resin. The antioxidant activity of LPF resin has been effectiveness in preventing cor- rosion on steel surfaces. When applied as an anti-corrosion coating and compared to industrially used CPF resins, LPF resin demonstrates its efficacy in such applications. Also, it should be noted that the impedance modulus of the elaborated resin coating remained consistently low throughout the entire immersion period, indicating its stable performance.
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    Novel palladium (II) complexes with iminocoumarin ligands : synthesis, characterisation, electrochemical behaviour, DFT calculations and biological activities, ADMET study and molecular docking
    (2022) Kerflani, Asma; Si Larbi, Karima; Rabahi, Amal; Bouchoucha, Afaf; Zaater, Sihem; Terrachet-Bouaziz, Souhila
    New Palladium (II) complexes with a series of iminocoumarin derivatives have been synthesized and charac- terized by analytical analysis, spectral methods, magnetic measurements and thermal studies. The experimental results indicated that the Pd(II) complexes are coordinated to the bidentate iminocoumarin derivatives with a distorted square planar geometry. The DFT calculations were performed in order to optimize the geometric structures, to calculate structural parameters and to explain the chemical reactivity of the synthesized com- pounds. Electrochemical behaviour of the synthesized compounds was studied by cyclic voltammetry. The antioxidant activity of free ligands and their Pd(II) complexes have been evaluated using the DPPH method. The antimicrobial activity was also evaluated in Vitro against two Gram-negative (E. coli, Klebsiella pneumonia), two gram-positive (Staphylococcus aureus, Enterococcus faecalis) and three fungal strains (Candida albicans, Candida tropicalis and Aspergillus niger) using the agar-diffusion method. The ADMET study was also accomplished in order to predict pharmacokinetic and toxicity of the synthesized compounds. Finaly, and in order to study the molecular interaction of the ligand L3 and its corresponding Pd(II) complex with the microbial enzymes; Docking studies were employed
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    Assessment of Some Biological Activities of Eucalyptus blakelyi Maiden Using the Essential Oil, Methanolic and Aqueous Extracts
    (Har Krishan Bhalla and Sons, 2020) Boukhalfoun, Leila; Kirouani, A.; Behidj, N.; Gana, S.
    Several species of Eucalyptus are used in folk medicine as an antiseptic, anti-inflammatory, and against respiratory infections, such as colds, sinus congestion and influenza. These species have shown potential antioxidant properties in addition to antimicrobial activities. In the present paper, we were interested in Eucalyptus blakelyi Maiden, a species belonging to the Myrtaceae family. Our study can be considered as the first detailed report on the chemical composition, antioxidant and antimicrobial activity of different extracts. The aim of the current study is to evaluate the biological activities of essential oils, methanolic and aqueous extracts of this plant. The present work was realized on leaves collected from National Institute for Forest Research (INRF) of Baïnem (Algiers, Algeria), and the results showed that essential oil’s yield obtained by hydrodistillation was 2.13 %. Actually, 15 compounds were identified by GC-MS profile, and the major compound was 1.8-cineole with 62.74 %. Indeed, the antiradical activity using the DPPH method has shown that methanolic and aqueous extracts had an interesting antioxidant ability with an IC50 of 0.33 and 0.39 mg/ ml respectively. The antimicrobial activity of the essential oil, methanolic and aqueous extracts on eleven microbial strains was evaluated using the aromatogram method. Thus, the methanolic extract proved to be the most active compared to the aqueous extract and the essential oil by inducing a maximum inhibition zones of 19.66 mm for Staphylococcus aureus ATCC29213 and 25.66 mm for Candida albicans. The results suggest potential applications of essential oil in food and extracts in pharmaceutical industry