Pd-Catalyzed Coupling of Bromo-N-(β-glucopyranpsyl)quinolin-2-ones with Amides: Synthesis of N-glucosyl-6BrCaQ Conjugates with Potent Anticancer Activity

Simple item page
dc.contributor.authorRedjdal, Wafa
dc.contributor.authorBenmahdjoub, Sara
dc.contributor.authorThanh Hyen Luong, Thi
dc.contributor.authorBenmerad, Belkacem
dc.contributor.authorLe Bideau, Franck
dc.contributor.authorVergnaud-Gauduchon, Juliette
dc.contributor.authorMessaoudi, Samir
dc.date.accessioned2024-05-08T08:23:48Z
dc.date.available2024-05-08T08:23:48Z
dc.date.issued2024
dc.description.abstractA series of N-glycosyl- 6BrCaQ conjugates was synthesized through a Pd-catalyzed cross-coupling reaction between brominated N-glycosyl quinolin-2-one derivatives and various nitrogen nucleophiles. Antiproliferative assays revealed that this new series of analogues represents a promising class of antitumor compounds as illustrated by the high biological activity observed for several derivatives towards different cancer cell lines compared to the non-glycosylated congeners.en_US
dc.identifier.issn1860-7179
dc.identifier.urihttps://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/cmdc.202400195
dc.identifier.urihttps://doi.org/10.1002/cmdc.202400195
dc.identifier.urihttps://chemistry-europe.onlinelibrary.wiley.com/doi/epdf/10.1002/cmdc.202400195
dc.identifier.urihttps://dspace.univ-boumerdes.dz/handle/123456789/13889
dc.language.isoenen_US
dc.publisherWiley-VCH GmbHen_US
dc.relation.ispartofseriesChemMedChemChemMedChem, e202400195(2024);pp. 1-8
dc.subjectN-glycosidesen_US
dc.subjectHPS90en_US
dc.subjectTRAP1en_US
dc.subjectBuchwald-Hartwig Cross-Couplingen_US
dc.subjectAntiproleferative activityen_US
dc.titlePd-Catalyzed Coupling of Bromo-N-(β-glucopyranpsyl)quinolin-2-ones with Amides: Synthesis of N-glucosyl-6BrCaQ Conjugates with Potent Anticancer Activityen_US
dc.typeArticleen_US

Files

Original bundle

Now showing 1 - 1 of 1
No Thumbnail Available
Name:
ChemMedChem - 2024 - Redjdal - Pd‐Catalyzed Coupling of Bromo‐N‐ ‐glucopyranpsyl quinolin‐2‐ones with Amides Synthesis of.pdf
Size:
1.42 MB
Format:
Adobe Portable Document Format
Download

License bundle

Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

Publications Internationales