Time-course of age-related temporal order memory decline in an object recognition paradigm in mice

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dc.contributor.authorBelblidia, Hassina
dc.contributor.authorFreret, Thomas
dc.contributor.authorLeger, Marianne
dc.contributor.authorSchumann-Bard, Pascale
dc.date.accessioned2023-03-13T08:11:26Z
dc.date.available2023-03-13T08:11:26Z
dc.date.issued2023
dc.description.abstractTemporal order memory refers to the ability to remember the order of occurrence of items across time. It is a critical feature of episodic memory that is often tested in rodents using spontaneous object recognition paradigms. However, impact of aging over performances of temporal order memory decline is barely known. Herein, we characterized here the effect of normal aging on the temporal order memory performances in NMRI mice between 3 and 19months of age, with an inter-session interval of 24h.We found that temporal order memory was impaired as soon as7 months of age. These results provide strong evidence that temporal order memory is particularly vulnerable to the deleterious effect of normal agingen_US
dc.identifier.issn01664328
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S0166432822004193
dc.identifier.urihttps://doi.org/10.1016/j.bbr.2022.114151
dc.identifier.urihttps://dspace.univ-boumerdes.dz/handle/123456789/11183
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofseriesBehavioural Brain Research/ Vol.437 (2023);pp. 1-4
dc.subjectMemory declineen_US
dc.subjectNMRI miceen_US
dc.subjectNormal agingen_US
dc.subjectObject recognitionen_US
dc.subjectTemporal order memoryen_US
dc.subjectY-mazeen_US
dc.titleTime-course of age-related temporal order memory decline in an object recognition paradigm in miceen_US
dc.typeArticleen_US

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