Keratoconus prognosis study for patients with corneal external mechanical stress mode

Abstract

A corneal numerical model was developed based on experimental previous studies, and gathered data from EKBASSIRA eye clinic. The cornea is considered a two layers 3D viscoelastic solid. Uniaxial and multiaxial cyclic loads has been applied on the Keratoconus and healthy corneas in order the emphasize the influence of eye rubbing on corneal applanation, loss of shape and biomechanical properties .A Finite element analysis simulation results have shown a significant difference between healthy and KC stages responses to those external loads, for a fixed intraocular pressure .Life time prognosis and classification algorithms using analytical life time computation and Artificial Neural Network approaches was then established to shed light on the severity of eye rubbing on the evolution and the progression rate of Keratoconus and its offset, for patients with subclinical, mild and advanced forms of the disease